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KMID : 0352419920110040608
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Keimyung Medical Journal
1992 Volume.11 No. 4 p.608 ~ p.611
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A comparative Study between HT 29 Colon Cancer Cell and Other Cells in c-myc Expression
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Abstract
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Activation of c-myc gene was evaluated by southern and Northern hybridization in HT29 colon cancer cells.
The amplification of c-myc which appears as a 2.4 Kb band in southern blots appeared as elevated levels ranging from 2 to 4 folds in HT 29 cells, but elevated expression of c-myc in Northern blot was not found. The amplification of c-myc is rare
event
in colorectal tumors.
Minor amplification of c-myc is not considered as an etiology of the colonic cancer at the present time but further study is needed in this regard.
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